033 Increased expression of IL-31, IL-31RA and OSMRβ in bullous pemphigoid
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چکیده
منابع مشابه
IL-17 Expression in Dermatitis Herpetiformis and Bullous Pemphigoid
Dermatitis herpetiformis (DH) and bullous pemphigoid (BP) are skin diseases associated with eosinophilic and neutrophilic infiltrations. Although cytokines are critical for the inflammatory process, there are single findings concerning concentration of IL-17 in bullous diseases. The goal of this study was to assess IL-17 expression in DH and BP patients. Skin biopsies were taken from 10 DH, 14 ...
متن کاملIL-31 receptor (IL-31RA) knockout mice exhibit elevated responsiveness to oncostatin M.
IL-31 signals through the heterodimeric receptor IL-31RA and oncostatin M receptor (OSMR), and has been linked with the development of atopic dermatitis, a Th2 cytokine-associated disease in humans. However, recent studies of IL-31RA knockout (KO) mice have suggested that IL-31 signaling may be required to negatively regulate Th2 type responses rather than exacerbate them. Because those studies...
متن کاملFollicular Helper T Cells (Tfh) and IL-21 Involvement in the Pathogenesis of Bullous Pemphigoid
The pathogenesis of bullous pemphigoid (BP) is characterized by the T cell-dependent production of autoantibodies. Recent studies have indicated that follicular T helper cells (Tfh), the key modulator of B cell activation and autoantibody production, are critical in the development of several autoimmune diseases. Tfh cells perform their functions via IL-21, their hallmark cytokine. In the prese...
متن کاملIntegrating longitudinal serum IL-17 and IL-23 follow-up, along with autoantibodies variation, contributes to predict bullous pemphigoid outcome
Bullous pemphigoid (BP) is an inflammatory autoimmune bullous disease involving cytokines and proteases in the process of blister formation. Recently, IL-17 and IL-23 were evidenced in lesional skin and serum of BP patients at time of diagnosis, but their involvement in disease outcome has still not been investigated yet. We then analysed IL-17 and IL-23 serum levels during the first months of ...
متن کاملHere, we performed an analysis of the OSMR gene and cutaneous expression patterns of cytokines and anti-microbial peptides (AMP) in a 42-year-old woman with a sporadic case of LA. MeTHOdS
© 2015 The Authors. doi: 10.2340/00015555-1829 Journal Compilation © 2015 Acta Dermato-Venereologica. ISSN 0001-5555 Lichen amyloidosis (LA), a variant form of primary localised cutaneous amyloidosis (PLCA), is a chronic itching skin disease, caused by the extracellular deposition of amyloid proteins in the dermis (1). This entity is clinically characterised by grouped hyperkeratotic papules wi...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2018
ISSN: 0022-202X
DOI: 10.1016/j.jid.2018.03.037